Keywords:

Human microbiome, Innate immunity 

Research interests:

1.Understanding the relationship of human microbiome and innate immunity 

2.Development of diagnosis antibodies for infectious pathogens

Selected Publications (# Co-first author):

1.He ZJ#, Chen JH#, Zhu X, An S, Dong XH, Yu JC, Zhang SH, Wu Y, Li G, Zhang Y, Wu JH, and Li MF (2018). NLRP3 Inflammasome Activation Mediates Zika Virus–Associated Inflammation. The Journal of Infectious Diseases. 217(12): 1942-1951.

2.Hu YW#, Chen JH#, Hu GP #, Yu JC, Zhu X , Lin YC, Chen SP * and Yuan J *. Statistical Research on the Bioactivity of New Marine Natural Products Discovered during the 28 Years from 1985 to 2012. (2015) Marine Drugs. 13(1)：202-211

3.He ZJ#, Zhu X, Wen WT, Yuan J, Zhu X, Hu YW, Chen JH, An S, Dong XH, Lin CJ, Yu JC,, Wu JH, Yang Y, Cai JC, Li J, Li MF. Dengue Virus Subverts Host Innate Immunity by Targeting Adaptor Protein MAVS.(2016) Journal of Virology. 90(16):7219-7230.

4.Hu Y, Dong X, He Z, Wu Y, Zhang S, Lin J, Yang Y, Chen J, An S, Yin Y, Shen Z, Zeng G, Tian H, Cai J, Yang Y, Guan H, Wu J, Li M, Zhu X. Zika virus antagonizes interferon response in patients and disrupts RIG-I-MAVS interaction through its CARD-TM domains. (2019) Cell and Bioscience. 7;9:46.

5.Wu Y, Yang X, Yao Z, Dong X, Zhang D, Hu Y, Zhang S, Lin J, Chen J, An S, Ye H, Zhang S, Qiu Z, He Z, Huang M, Wei G, Zhu X. C19orf66 interrupts Zika virus replication by inducing lysosomal degradation of viral NS3.(2020) PLoS Neglected Troptical Disease. Mar 9;14(3):e0008083.