Aging related diseases, Microbiome-host interactions, Bioinformatics, Multi-omics, Big data analysis, Microbiome intervention
1.Microbiome-host interactions in aging related diseases including metabolic diseases, stroke and cognitive impairment.
2.Understanding human microbiome through multi-omics data analysis, including 16S rRNA gene, metagenome, meta-transcriptome, metabolome and etc.
3.Developing new techniques in bioinformatics and biostatistics in human microbiome data analysis
4.Exploring novel strategies in microbiome intervention
Selected Publications (# First and * Correspondence):
1.He Y#, Wu W#, Zheng HM#, Li P#, McDonald D, Sheng HF, Chen MX, Chen ZH, Ji GY, Zheng ZDX, Mujagond P, Chen XJ, Rong ZH, Chen P, Lyu LY, Wang X, Wu CB, Yu N, Xu YJ, Yin J, Raes J, Knight R, Ma WJ*, Zhou HW* (2018) Regional variation limits applications of healthy gut microbiome reference ranges and disease models. Nature Medicine 24:1532-1535 (Cover story)
2.He Y#, Wu W#, Wu S#, Zheng HM#, Li P#, Sheng HF, Chen MX, Chen ZH, Ji GY, Zheng ZDX, Mujagond P, Chen XJ, Rong ZH, Chen P, Lyu LY, Wang X, Xu JB, Wu CB, Yu N, Xu YJ, Yin J, Raes J, Ma WJ*, Zhou HW* (2018) Linking gut microbiota, metabolic syndrome and economic status based on a population-level analysis. Microbiome 6:172
3.He Y#, Caporaso JG, Jiang XT, Sheng HF, Huse SM, Rideout JR, Edgar RC, Kopylova E, Walters WA, Knight R, Zhou HW* (2015) Stability of operational taxonomic units: an important but neglected property for analyzing microbial diversity. Microbiome 3:20
4.T. Liu#, X. Chen#, Y. Xu#, W. Wu, W. Tang, Z. Chen, G. Ji, J. Peng, Q. Jiang, J. Xiao, X. Li, W. Zeng, X. Xu, J. Hu, Y. Guo, F. Zou, Q. Du, H. Zhou, Y. He*, and W. Ma*, Gut microbiota partially mediates the effects of fine particulate matter on type 2 diabetes: Evidence from a population-based epidemiological study. Environment International, 2019. 130.
5.R.-T. Xu#, C.-H. Tan#, J.-J Zhu#, X.-L. Zeng, X.-X. Gao, Q.-H. Wu, Q. Chen, H.-D. Wang, H.-W. Zhou, Y. He*, S.-Y. Pan*, and J. Yin*, Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death. Critical Care, 2019. 23:195