Immunometabolism, T-cell, Tumor Immunotherapy
1.Understanding the metabolic regulation of T-cell function and antitumor immunity.
2.Development of novel immunometabolism-based cancer immunotherapeutic methods.
1.National Excellent Young Scholar Award, 2018, by National Science Foundation of China
2.Young Pearl River Scholar, 2017, by Department of Education of Guangdong Province
Selected Publications (*Co-first author, #Correspondence author):
1.Yang W*, Bai Y*, Xiong Y, Zhang J, Chen S, Zheng X, Meng X, Li L, Wang J, Xu CG, Yan C, Wang L, Chang CCY, Chang TY, Zhang T, Zhou P, Song BL, Liu W, Sun SC, Liu X, Li BL#, Xu C#. Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism. Nature. 2016, 531(7596), 651-655.
2.Shi X*, Bi Y*, Yang W*, Guo X, Jiang Y, Wan C, Li L, Bai Y, Guo J, Wang Y, Chen X, Wu B, Sun H, Liu W, Wang J, Xu C. Ca2+ regulates T cell receptor activation by modulating the electrostatic property of phospholipids, Nature. 2013, 493(7430), 111-115. (*co- first author)
3.Yang W*, Pan W*，Chen S*, Trendel N*, Jiang S*, Xiao F, Xue M, Wu W, Peng Z, Li X, Ji H, Liu X, Jiang H, Wang H, Shen H, Dushek O#, Li H#, Xu C#. Dynamic regulation of CD28 conformation and signaling by charged lipids and ions. Nat Struct & Mol Biol, 2017, 24 (12) 1081-1092
4.Xiang W*, Shi R*, Kang X*, Zhang X*, Chen P, Zhang L, Hou A, Wang R, Zhao Y, Zhao K, Liu Y, Ma Y, Luo H, Shang S, Zhang J, He F, Yu S, Gan L, Shi C, Li Y#, Yang W#, Liang H#, Miao H#. Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression. Nature Communications. 2018 Jul 3;9(1):2574