Keywords:

Stroke, Gut Microbiota 

Associations:

Vice Director, Cerebrovascular Disease Branch, Guangdong Medical Association;

Member of the Standing Committee and Secretary of Severe Cerebral Vascular Disease Expert Committee, Stroke Prevention Committee, National Health and Family Planning Committee;

Deputy Director of Management Board of Neurology Department, Guangdong Medical Industry Association;

Executive Director of Guangdong Provincial Stroke Association;

Member of Guangdong Provincial Technology Review Expert Base;

Guangdong Provincial Exceptional Young Medical Talent 2018

Research interests:

1.Understanding the role of human microbiome in stroke and neurocritical care 

2.Development of novel prognosis biomarkers through metabolomics techniques

3.Development of potential therapeutic strategies for stroke and neurocritical care

Research funds:

1.National Natural Science Foundation of China, 2018

2.National Natural Science Foundation of China, 2016 

3.Natural Science Foundation of Guangdong Province, 2017

4.Clinical Research Initiative of Southern Medical University, 2016

5.Special Fund of Clinical Research, Nanfang Hospital, Southern Medical University, 2019

Selected Publications (#First author, * Correspondence author):

1. Xu Ruoting#, Tan Chuhong#, Zhu Jiajia#, Zeng Xiuli, Gao Xuxuan, Wu Qiheng, Chen Qiong, Wang Huidi, Zhou Hongwei, He Yan*, Pan Suyue*, and Yin Jia*. Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death. Crit Care, 2019,23:195. 

2. Yin Jia#, Liao Shuoxi#, He Yan, Wang Shan, Xia Genghong, Liu Feitong, Zhu Jiajia, You Chao, Chen Qiong, Zhou Liang, Pan Suyue, Zhou Hongwei*. Dysbiosis of Gut Microbiota With Reduced Trimethylamine-N-Oxide Level in Patients With Large-Artery Atherosclerotic Stroke or Transient Ischemic Attack. J Am Heart Assoc. 2015;4(11):e002699.

3. Zeng Xiuli#, Gao Xuxuan#, Peng Yu, Wu Qiheng, Zhu Jiajia, Tan Chuhong, Xia Genghong, You Chao, Xu Ruoting, Pan Suyue, Zhou Hongwei, He Yan*, Yin Jia*. Higher Risk of Stroke Is Correlated With Increased Opportunistic Pathogen Load and Reduced Levels of Butyrate-Producing Bacteria in the Gut. Front Cell Infect Microbiol. 2019;9:4. 

4. Xia Genghong#, You Chao#, Gao Xuxuan, Zeng Xiuli, Zhu Jiajia, Xu Kaiyu, Tan Chuhong, Xu Ruoting, Wu Qiheng, Zhou Hongwei, He Yan*, Yin Jia*. Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke. Front Neurol. 2019;10:397.

5. Chuhong Tan#, Huidi Wang#, Xuxuan Gao, Ruoting Xu, Xiuli Zeng, Ziming Cui, Jiajia Zhu, Qiheng Wu, Genghong Xia, Hongwei Zhou, Yan He*, Jia Yin*. Dynamic Changes and Prognostic Value of Gut Microbiota-Dependent Trimethylamine-N-Oxide in Acute Ischemic Stroke. Front Neurol. 2020, 11:29.

6. Xu Kaiyu#, Xia Genghong#, Lu Junqi, Chen Muxuan, Zhen Xin, Wang Shan, You Chao, Nie Jing, Zhou Hongwei*, Yin Jia*. Impaired renal function and dysbiosis of gut microbiota contribute to increased trimethylamine-N-oxide in chronic kidney disease patients. Sci Rep. 2017;7(1):1445.

7. Yin Jia#, M Prabhakar#, Wang Shan, Liao Shuo-Xi, Peng Xin, He Yan, Chen Yi-Ran, Sheng Hua-Fang, Su Jin, Chen Ye, Jiang Yun-Xia, Zhang Guo-Xia*, Zhou Hong-Wei*. Different Dynamic Patterns of beta-Lactams, Quinolones, Glycopeptides and Macrolides on Mouse Gut Microbial Diversity. Plos One, 2015, 10(5):e0126712-e0126712.