Prof. Li-Ping HUANG(黄莉萍), PhD
Professor of Obstetrics&Gynecology, OB&GYN department, Nanfang Hospital, SMU
Doctoral Supervisors of Obstetrics&Gynecology, SMU
Visiting Scholar at National Institutes of Health, US
Email: lphuang2006@126.com


High-risk pregnancy, human microbiome 

Professional recognition:

1. Young member of Obstetrics and Gynecology Branch of Chinese Medical Doctor Association

2. Young member of the Perinatal Medicine Branch of the Chinese Medical Association

3. Deputy director of Youth Committee of the Perinatal Medicine Society of Guangdong Medical Association

4. Committee member of Professional Committee of Maternal and Fetal Medicine of Guangdong Health Management Committee 

5. Member of Guangdong Provincial Obstetric Critical Care Team

6. Editor of Journal of Molecular Diagnosis and Therapy.

Cover stories of Li-Ping HUANG’s team:

Hong-Wei ZHOU(周宏伟)
Volume 69 Issue 3, March 2020
Gut microbiome and preeclampsia
Night view of the beautiful Canton Tower in Guangzhou, Guangdong Province, China. Read in this issue the excellent work by Chen et al on the role of the gut microbiota in pre-eclampsia.
Major finding:
1.Inoculation of the gut microbiome from patients with PE triggered a significantly higher blood pressure before pregnancy and PE-like phenotypes during pregnancy, including worsened hypertension, exacerbation of proteinuria and intrauterine growth restriction.
2.Higher levels of total bacteria and Fusobacterium and an altered microbiota profile were identified in PE placenta samples compared with in normotensive samples.
3.Gut microbiota screening shows potential for predicting PE onset and provides a new approach for the prevention and treatment of this disease.

Selected Publications (* Correspondence author):

1.Chen X, Li P, Liu M, Zheng HM, He Y, Chen MX, Tang WL, Yue XJ, Huang YX, Zhuang LL, Wang ZJ, Zhong M, Ke GB, Hu HY, Feng YL, Chen Y, Yu YH*, Zhou HW*, Huang LP* (2020) Gut dysbiosis induces the development of preeclampsia through bacterial translocation. Gut 69:513-522 (Cover story)

2.Huang YF, Bo Situ, Huang LP, Cao YS, Sui H, Ye XY, Jiang XJ, Liang AF, Tao ML, Luo SH, Zhang Y, Zhong M, Zheng L* (2020) Nondestructive identification of rare trophoblastic cells by endoplasmic reticulum staining for noninvasive prenatal testing of monogenic diseases. Advanced Science 7(7):1903354. 

3.Huang L, Qin Y, Zuo Q, Bhatnagar K, Xiong J, Merlino G, Yu Y* (2018) Ezrin mediates both HGF/Met autocrine and non-autocrine signaling-induced metastasis in melanoma. Int J Cancer 142(8):1652-1663.

4.Yue X, Sun Y, Zhong M, Ma Y, Wei Y, Sun F, Xiao L, Liu M, Chen J, Lai Y, Yan C, Huang L*, Yu Y*(2018) Decreased expression of fibroblast growth factor 13 in early-onset preeclampsia is associated with the increased trophoblast permeability. Placenta 62:43-49.

5.Zuo, Q., J. Liu, L. Huang, Y. Qin, T. Hawley, C. Seo, G. Merlino & Y. Yu (2018) AXL/AKT axis mediated-resistance to BRAF inhibitor depends on PTEN status in melanoma. Oncogene 37: 3275-3289.

6.Chen, Y., L. Huang, S. Wang, T. Liu, Y. Wu, J. L. Li & M. Li (2017) WAP four-disulfide core domain protein 2 promotes metastasis of human ovarian cancer by regulation of metastasis-associated genes. J Ovarian Res 10: 40.

7.Jia Bei, Huang Liping, Chen Yaoyu, Liu Siping, Chen Cuihua, Xiong Ke, Song Lanlin, Zhou Yulai, Yang Xinping, Zhong Mei* (2017) A novel contiguous deletion involving NDP, MAOB and EFHC2 gene in a patient with familial Norrie disease: bilateral blindness and leucocoria without other deficits. J. Genet 96: 1015-1020.

8.Liu H, Huang L, Chen Y, Guo L, Li L, Zhou H, Luan T* (2015) Simultaneous determination of polycyclic musks in blood and urine by solid supported liquid-liquid extraction and gas chromatography-tandem mass spectrometry. Journal of Chromatography B, Analytical technologies in the biomedical and life sciences 992:96-102.

9.Jin J, Pan SL, Huang LP, Yu YH, Zhong M, Zhang GW* (2015) Risk factors for adverse fetal outcomes among women with early- versus late-onset intrahepatic cholestasis of pregnancy. Int J Gynaecol Obstet 128: 236-40.

10.Huang QT, Wang SS, Zhang M, Huang LP, Tian JW, Yu YH, Wang ZJ, Zhong M* (2013) Advanced oxidation protein products enhance soluble Fms-like tyrosine kinase 1 expression in trophoblasts: a possible link between oxidative stress and preeclampsia. Placenta 34(10):949-52.

11.Huang LP, Yu YH*, Sheng C, Wang SH (2012) Up-regulation of cadherin 17 and down-regulation of homeodomain protein CDX2 correlate with tumor progression and unfavorable prognosis in epithelial ovarian cancer. Int. J. Gynecol. Cancer 22: 1170-6.