MMC Hongwei Zhou's team makes progress in the bidirectional interaction between stroke and intestinal flora



Recently, the studies paid for with Professor Zhou HongWei's team and Yin's team have revealed the two-way interaction between stroke and intestinal flora disorders. Ischemic stroke will quickly cause intestinal flora disorders and excessive growth of Enterobacteriaceae bacteria, which in turn will aggravate cerebral infarction. This study provides a new idea with translational value for clinical prognosis prediction and prevention and treatment intervention. Rapid Gut Dysbiosis Induced by Stroke Exacerbates Brain Intention in Turn was published in Gut (Impact Factor 17.943).

Zhou's team found that there were dynamic intestinal dysregulation and recovery in patients with ischemic stroke,  and the enrichment of Enterobacteriaceae could predict a poor prognosis in patients. Animal experiments have shown that cerebral ischemia can rapidly cause intestinal ischemia-reperfusion injury in mice. Excessive nitrate is produced through free radical reactions, resulting in dysregulation of the flora and expansion of the Enterobacteriaceae. The excessive proliferation of Enterobacteriaceae aggravates systemic inflammation and cerebral infarction through the LPS-TLR4 pathway. Using aminoguanidine or superoxide dismutase to reduce the production of nitrate, or using tungstate to inhibit the bacterial nitrate respiration, can inhibit the growth of Enterobacteriaceae bacteria, thus alleviating systemic inflammation and cerebral infarction in mice.