Microbiome and Maternal-Neonatal Diseases



The maternal microbial compositions play a major effect to the early-life microbiome colonize which has a powerful influence in human long-term health. MMC focus on the link between the human microbiome and maternal-neonatal diseases, such as Preterm, PROM, Preeclampsia, ASD and etc. We have revealed that gut microbiome dysbiosis was associated with Preeclampsia and verified that gut microbiome dysbiosis induce immune imbalances and intestinal barrier damage, the microbiota translocation to the placental, contributing to poor placentation in mice.

It is important to understand the microbiome functions of maternal and neonatal diseases and determine the mechanism of diseases. Intervention in intestinal flora maybe provides a new approach for further therapy.

Publication list:

1. Chen X, Li P, Liu M, et al. Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation. Gut. 2020:1-10. doi:10.1136/gutjnl-2019-319101

2. Liu F, Li J, Wu F, Zheng H, Peng Q, Zhou H. Altered composition and function of intestinal microbiota in autism spectrum disorders: a systematic review. Transl Psychiatry. 2019;9(1). doi:10.1038/s41398-019-0389-6

3.Yi-E Huang#, Yan Wang#, Yan He, Yong Ji, Li-Ping Wang, Hua-Fang Sheng, Min Zhang, Qi-Tao Huang, Dong-Jing Zhang, Jing-Jing Wu, Mei Zhong*,  Hong-Wei Zhou*, Homogeneity of the Vaginal Microbiome at the Cervix,  PosteriorFornix,  and Vaginal Canal in Pregnant Chinese Women, Microbial Ecology, 2015.2. 1, 69(2): 407~414

4. Mu-Biao Liu*#, Su-Rong Xu, Yan He, Guan-Hua Deng, Hua-Fang Sheng, Xue-Mei Huang, Cai-Yan Ouyang, Hong-Wei Zhou*, Diverse Vaginal Microbiomes in Reproductive-Age Women with Vulvovaginal Candidiasis, PLos One, 2013.11.12, 8(11)