The maternal microbial compositions play a major effect to the early-life microbiome colonize which has a powerful influence in human long-term health. MMC focus on the link between the human microbiome and maternal-neonatal diseases, such as Preterm, PROM, Preeclampsia, ASD and etc. We have revealed that gut microbiome dysbiosis was associated with Preeclampsia and verified that gut microbiome dysbiosis induce immune imbalances and intestinal barrier damage, the microbiota translocation to the placental, contributing to poor placentation in mice.
It is important to understand the microbiome functions of maternal and neonatal diseases and determine the mechanism of diseases. Intervention in intestinal flora maybe provides a new approach for further therapy.
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