Microbiome and infectious disease



Human microbiome plays a pivotal role in infectious diseases. On the one hand, the microbiota can protect the host from infections both by modulating immune responses and by mediating colonization resistance. On the other hand, it can also act as a reservoir for opportunistic microorganisms that can overgrow under varies circumstances, which significantly complicating diseases by contributing to inflammatory immune responses or disrupting intestinal barrier functions. MMC is keen to understand the complex interactions between host and microbiota in different kinds of infections, especially in sepsis, and excavate translational potential of microbiome in preventing or treating those infections.  

 Publication list:

1. Tan Xi-Lan(#); Liu Hai-Yue(#); Long Jun; Jiang Zhao-Fang; Luo Yue-Mei; Zhao Xin; Cai Shu-Min; Zhong Xiao-Zhu; Cen Zhong-Ran; Su Jin; Zhou Hong-Wei(*), Septic patients in the intensive care unit present different nasal microbiotas, Future Microbiology, 2019, 10.2217/fmb-2018-034

2. Zhou Zu-Yi(#), Tang Wen-Li, Ou Jin-Xiang, Li Pan, Ling Yong-Ji, Lv Yan-Li, Zhou Hong-Wei(*), Chen Mu-Xuan(*). Vaginal dysbiosis dominated by miscellaneous bacteria correlates with more severe clinical symptoms. Infect Genet Evol. 2020 Apr;79:104138. doi: 10.1016/j.meegid.2019.104138. Epub 2019 Dec 10. PMID: 31841701.

3. Zhou You-Lian(#); Xu Zhenjiang-Zech(#); He Yan(#); Yang Yun-Sheng; Liu Le; Lin Qian-Yun; Nie Yu-Qiang; Li Ming-Song; Zhi Fa-Chao; Liu Si-De; Amir Amnon; Gonzalez Antonio; Tripathi Anupriya; Chen Min-Hu; Wu Gary D.; Knight Rob; Zhou Hong-Wei(*); Chen Ye(*), Gut Microbiota Offers Universal Biomarkers across Ethnicity in Inflammatory Bowel Disease Diagnosis and Infliximab Response Prediction , mSystems, 2018, 3(1): e00188

4. Hou Jin(#); Zheng Hui-Min(#); Li Pan; Liu Hai-Yue; Zhou Hong-Wei(*); Yang Xiao-Jun(*), Distinct shifts in the oral microbiota are associated with the progression and aggravation of mucositis during radiotherapy , Radiotherapy and Oncology, 2018, 129(1): 44~51

5. Liu Hai-Yue(#); Zhang Shi-Yu(#); Yang Wan-Ying; Su Xiao-Fang; He Yan; Zhou Hong-Wei(*); Su Jin(*),Oropharyngeal and Sputum Microbiomes Are Similar Following Exacerbation of Chronic Obstructive Pulmonary Disease , Frontiers in Microbiology, 2017, 8: 1163

6. Zhu Xiao-Xia(#); Yang Xiao-Jun(#); Chao Yi-Lan; Zheng Hui-Min; Sheng Hua-Fang; Liu Hai-Yue; He Yan; Zhou Hong-Wei(*), The Potential Effect of Oral Microbiota in the Prediction of Mucositis During Radiotherapy for Nasopharyngeal Carcinoma , EBioMedicine, 2017, 18: 23~31

7. Gong Shen-Hai, Yan Zheng-Zheng, Liu Zhan-Guo, Niu Meng-Wei, Fang Heng, Li Na, Huang Chen-Yang, Li Lei, Chen Gui-Ming, Luo Hai-Hua, Chen Xiao-Jiao, Zhou Hong-Wei, Hu Jing-Juan, Yang Wei, Huang Qiao-Bing, Bernd Schnabl , Chang Ping(*), Timothy R Billiar , Jiang Yong(*) , Chen Peng(*) Intestinal microbiota mediates the susceptibility to polymicrobial sepsis-induced liver injury by granisetron generation in mice. Hepatology, 69 (4), 1751-1767 Apr 2019

8. Liu Zhan-Guo, Li Na, Fang Heng, Chen Xiao-Jiao, Guo Yue-Xun, Gong Shen-Hai, Niu Meng-Wei, Zhou Hong-Wei, Jiang Yong, Chang Ping(*)  , Chen Peng(*) Enteric Dysbiosis Is Associated With Sepsis in Patients. FASEB J, 33 (11), 12299-12310 Nov 2019

9. Liu Le, Liang Li-Ping, Liang Hui-Fen, Wang Ming-Ming, Lu Bing-Yun, Xue Meng, Deng Jun, and Chen Ye(*). Fusobacterium nucleatum Aggravates the Progression of Colitis by Regulating M1 Macrophage Polarization via AKT2 Pathway. Front Immunol. 2019; 10: 1324.